Are there any known contraindications with combining different types of cannabinoids, such as cbd and delta-8-thc?

Cannabinoid levels can be increased with other medications. Delta-9-tetrahydrocannabinol (THC) and cannabidiol are pharmacologically active cannabinoids in. Sedatives such as Ambien, Lunesta and Benadryl. Cannabidiol (CBD) is an active ingredient found in marijuana, but it doesn't cause the same mind-altering “high” that tetrahydrocannabinol (THC) causes.

Research shows that CBD can have several benefits for various ailments, such as pain, inflammation and anxiety. Epidiolex, an FDA-approved CBD drug, is used to treat certain types of seizures. A systematic review conducted by Stout & Cimino (201) showed that P-450 participates in the metabolism of several exogenous cannabinoids, for example, tetrahydrocannabinol (THC); CYP2C9, 3A, cannabidiol (CBD); CYPs 2C19, 3A and cannabinol (CBN); CYP2C9, 3A, which is supported by clinical data on the metabolism of THC and CBD. It's a good idea to keep a list of current medications and work with a healthcare provider to ensure that CBD is taken safely.

For example, many CBD products are not tested for purity and may contain higher or lower concentrations than those indicated on the label. While CBD may be useful for some patients, more research is needed to evaluate the safety and effectiveness of CBD. Because CBD is processed in the liver, along with many other medications, older adults may be at greater risk of high levels of the drug in the body and of suffering adverse effects. Cancer patients are generally given a cocktail of drugs to overcome the resilient complexity of cancer, most often with combinatory chemotherapy agents along with relieving medications, such as antiemetics, appetite stimulants, and pain relievers.

CBD is commonly used together with anticonvulsants or antiepileptics, but it is known to interact with several antiepileptic drugs.